An: 2014, Nr.4, Articol Nr. 6
PHENOTYPES OF STROMAL INFLAMMATORY CELLS IN BREAST CANCER. TISSUE CYTOMETRY. RECIPROCAL TUMOR – MICROENVIRONMENT INTERACTIONS
Simona Partene-Vicoleanu, Mihaela Mitrea, A.H. Nedelcu - University of Medicine and Pharmacy “Gr.T. Popa”, Iaşi, Department of Anatomy and Embryology
Dorelia Lucia Călin - University of Medicine and Pharmacy “Gr.T. Popa”, Iaşi, Department of Cariology and Restorative Odontotherapy
PHENOTYPES OF STROMAL INFLAMMATORY CELLS IN BREAST CANCER. TISSUE CYTOMETRY. RECIPROCAL TUMOR – MICROENVIRONMENT INTERACTIONS (Abstract): Breast cancer progression is associated with and dependent upon robust neovascularization. Tumour-associated ‘normal’ cells, such as immune/inflammatory cells, endothelial cells and stromal cells, conspire with cancer cells in promoting this process. In particular, infiltrating immune/inflammatory cells secrete a diverse repertoire of growth factors and proteases that enable them to enhance tumour growth by stimulating angiogenesis . The presence in microenvironment of Ly T CD4 + and Ly T CD8 + suggests involvement of the two subpopulations in antigenic modulation and epitopes editing which could correspond to a selection of aggressive clones by the removal of those susceptible to lysis following the attack of cytotoxic lymphocytes with predominant CD8 + phenotype.
Key words: CYTOTOXIC LYMPHOCYTES T, INFILTRATING IMMUNE CELLS, TISSUE CYTOMETRY, TUMOR MICROENVIRONMENT