Abstract
An: 2010, Nr.1, Articol Nr. 11
Title: 

ION CHANNELS AND SOME PATHOGENIC NEUROLOGICAL DISORDERS. PQ CALCIUM CHANNELS AND FAMILY HEMIPLEGIA MIGRAINE

Authors: 

      B. Oprişan - University of Medicine and Pharmacy “Gr.T.Popa” Iasi, Faculty of Medicine, Discipline of Biophysics and Medical Physics
      C.I. Stan, Cristina Luca, O.I. Motaş - University of Medicine and Pharmacy “Gr.T.Popa” Iasi, Faculty of Medicine, Discipline of Anatomy
      ION CHANNELS AND SOME PATHOGENIC NEUROLOGICAL DISORDERS. PQ CALCIUM CHANNELS AND FAMILY HEMIPLEGIA MIGRAINE (Abstract): During the last decades, the major progress from the domain of the biophysics, biochemistry, genetics, etc. have helped us identify the etiology and the physiopathological mechanisms of some neurological diseases. The membrane is a mosaic of ion channels distributed either in accordance with the role of different neuronal segments and the location of the neuron or at the level of the central or peripheral nervous system. The ion channels can be genetically affected by the action of various factors, generating channelopathies. The familial hemiplegic migraine is one from this category, determined by gene mutations of the calcium voltage-dependent channels, Cav 2.1, generators of P/Q currants but also of Na+, K+, ATP from the level of the astrocytes. The recent discoveries have mentioned that the clinical symptomatology of the familial hemiplegic migraine is determined by the gene mutations that code the Nav 1.1 channels in the case of certain patients, opening new perspectives for research especially if we take into account the fact that the same channelopathy can generate different neurological diseases. It is obvious that a certain ion channel becomes a therapeutical target but the molecule that acts targeted must be discovered, on the modified channel.
Key words: VOLTAGE-DEPENDENT ION CHANNELS, GENE MUTATIONS, ETIOPATOGENIE MODELS
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