Abstract
An: 2021, Nr.2, Articol Nr. 11
Title: 

ASTROCYTIC TUMORS. A REVIEW

Authors: 

      G.C. Moroşan, Ana-Maria Dumitrescu - „Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania, Doctoral School
      L.C. Gavril, Roxana Florentina Şufaru - „Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania, Department of Morphofunctional Sciences I
      Andreea-Cătălina Rusu, Nicoleta Dumitrescu - „Socola” Institute of Psychiatry, Iaşi, Romania
      ASTROCYTIC TUMORS. A REVIEW (Abstract): Gliomas are primary brain tumors that grow from glial cells. These include about 50-55% of all brain tumors. The notion of glial formation incorporates a heterogeneous group of tumors, biological features, treatment and prognosis of which can vary significantly. Currently, glial tumors are tumors that originate from oligodendroglial and astrocytic cells. Glioblastomas and gliomas are the most common brain tumors, with an annual incidence of 5.5 per 100,000 population or 18,000 new diagnoses per year. These tumors are usually associated with a poor prognosis and poor quality of life.The brain is the major organ of the central nervous system that controls and processes most of the body activities. Therefore, the most aggressive brain tumor, namely glioblastoma but also the metastases of other tumors with brain location have a reserved prognosis and a short survival time. Brain tissue has peculiarities compared to other tissues in the body, and the specific microenvironment comprising stem cells and blood-brain barrier, significantly influencing the low rate of glioblastoma metastasis outside the brain. The clinical manifestations of astrocytic tumors depend on the location and pace of tumor development. Well-differentiated diffuse astrocytomas may remain without manifestations for a relatively long period of time. At the same time, people who have developed a glioblastoma may show a rapid deterioration of the general condition. It is very important to understand the morphological classification of glial tumors because complete knowledge of tumor structures and the degree of malignancy can help optimize treatment for each tumor.
Key words: ASTROCYTE TUMORS, BRAIN, GLIOMA, GLIOBLASTOMA
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