Abstract
An: 2021, Nr.2, Articol Nr. 10
Title: 

GENETIC SUBSTRATE OF CARDIOVASCULAR INJURY IN SARS-COV2 INFECTION

Authors: 

      Maria Magdalena Leon-Constantin, Alexandra Maştaleru, Mădălina Zota, Florin Mitu - “Grigore T Popa” University of Medicine and Pharmacy – Iasi, Romania, Faculty of Medicine, Department of Medical Specialties I
      Ruxandra Aanicăi - Obstetrics and Gynecology Hospital Cuza Vodă
      Sabina Alexandra Cojocariu - “Grigore T Popa” University of Medicine and Pharmacy – Iasi, Romania, Faculty of Medicine, PhD student
      GENETIC SUBSTRATE OF CARDIOVASCULAR INJURY IN SARS-COV2 INFECTION (Abstract): COVID19 (Coronavirus disease 2019) is a disease caused by a new strain of coronavirus known as SARS-CoV2 (Severe Acute Respiratory Syndrome Coronavirus 2), with a significant virulence, which caused a global expansion in a very short time. Clinically, the manifestations are extremely polymorphic, from asymptomatic patients to deaths, due to multiple organ dysfunctions. The virus can cause cardiac injury (myocarditis, pericarditis, vasculitis and arrhythmias) even in young patients, without known risk factors or comorbidities. This review draws attention to the involvement of genetic factors, identified so far as modulators of the risk of SARS-CoV2 infection, in the occurrence of cardiac manifestations. Myocardial ACE2 expression and TMPRSS2 coexpression appear to be directly related to adverse outcome. Also, the newly reported defects in the TLR7 gene represent the immune deficiency that increases the risk of progression to a severe disease with multiple organ dysfunctions. In order to identify the optimal treatment of cardiovascular diseases and to minimize the long-term effects, it is necessary to monitor the long-term health of cured patients.
Key words: SARS-COV2, CARDIAC INJURY, GENETICS
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