Abstract
An: 2018, Nr.1, Articol Nr. 9
Title: 

THE ROLE OF LI-CADHERIN IN DIGESTIVE TUMORS FOLLOWING THE GROWTH-INVASION-METASTASIS SEQUENCE – A LITERATURE REVIEW

Authors: 

      V. Ianole, Irene Spiridon - “Grigore T. Popa” University of Medicine and Pharmacy Iasi, Romania Ph.D. student; “Sf. Spiridon” County Clinical Emergency Hospital Iasi, Iasi, Romania, Department of Morpho-Functional Sciences I (Pathology)
      THE ROLE OF LI-CADHERIN IN DIGESTIVE TUMORS FOLLOWING THE GROWTH-INVASION-METASTASIS SEQUENCE– A LITERATURE REVIEW (Abstract): Recent data show that less than 0.02% of disseminated tumor cells have the capability/quality to produce a metastasis. Nevertheless, metastases are a major clinical challenge and are responsible for the great majority of deaths in tumor pathology worldwide. Alongside angiogenesis, adhesion molecules play a major role in tumor progression and in the metastatic process. LI-cadherin or CDH17 is considered an atypical cadherin, expressed in adenocarcinomas of the digestive tract (gastric adenocarcinoma, colorectal adenocarcinoma, pancreatic adenocarcinoma, cholangiocarcinoma and hepatocellular carcinoma) and is considered to be a useful marker for metastasis diagnosis in tumors of unknown primary origin. Levels of LI-cadherin expression are correlated with lymph node metastasis, advanced TNM stage, early tumor relapses, low survival rate and relates to the tumor cells ability to gain an aggressive phenotype in some tumors and to the tumor cell migration, adhesion and invasion features LI-cadherin proves to be a promising molecule having a potential role as prognostic factor and therapeutic target. Also has a higher sensitivity and specificity then CDX2 and CK 20 as diagnosis marker for gastric and colon adenocarcinoma and for the diagnosis of metastasis with primary digestive tumor.
Key words: DIGESTIVE TUMORS, LI-CADHERIN, CDH17, METASTASIS, CADHERINS
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