Abstract
An: 2015, Nr.2, Articol Nr. 22
Title:
PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL CARDIAC HUNT – AN ANATOMICAL APPROACH FOR CARDIOLOGISTS
Authors:
Ruxandra Irina Negoi, F. Filipoiu, A.T. Ispas, G. Lupu - University of Medicine and Pharmacy “Carol Davila”, Bucharest, Anatomy Department
Ioana Ghiorghiu - University of Medicine and Pharmacy “Carol Davila”, Bucharest; Children’s Hospital “Dr. Victor Gomoiu”
Diana Loreta Paun - University of Medicine and Pharmacy “Carol Davila”, Bucharest; “CI Parhon” National Institute of Endocrinology
I. Negoi - University of Medicine and Pharmacy “Carol Davila”, Bucharest; Emergency Hospital of Bucharest, General Surgery Department
Carmen Ghinghina - University of Medicine and Pharmacy “Carol Davila”, Bucharest; Institute for Emergencies in Cardiovascular Diseases “C.C. Iliescu”, Cardiology Department
PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL CARDIAC SHUNT-AN ANATOMICAL APPROACH FOR CARDIOLOGISTS (Abstract): Pulmonary arterial hypertension associated with congenital cardiac shunts (CCS-PAH) represents one of the most common causes of severe morbidity and premature mortality in patients with congenital heart diseases. Retrospective study of patients with CCS-PAH admitted in the Cardiology Department of Institute for Emergencies in Cardiovascular Diseases “C.C. Iliescu” of Bucharest, during 5 years. Systematic review of the literature was undertaken, using an electronic search of U.S. National Library of Medicine National Institutes of Health PubMed/MEDLINE, EMBASE, Google Scholar, and ISI Web of Knowledge, to identify original articles and reviews about the subject. We have selected for the current study 79 patients. The most frequent observed cardiac malformations were atrial septal defects (ASD) - 58%, ventricular septal defects (VSD) - 47%, anomalies of the pulmonary venous drainage – 13%, and persistent arterial duct (PAD) - 10%. Most of the congenital heart defects were found in a higher percentage to female patients, persistent arterial duct (PAD) - 87.5%, atrial septal defects (ASD) - 76%, anomalies of the pulmonary venous drainage - 70%, while ventricular septal defects (VSD) were observed with an equal distribution between the two sexes (p = 0.024). The current mean age of patients with VSD was 23 ± 13 years, about 20 years lower than that of patients with ASD (44 ± 23 years, p < 0.05), and with 15 years lower than that of the anomalous pulmonary venous drainage (39 ± 24 years, p <0.05). In patients with atrial septal defects the cardiac shunt occurs after the maturation of the pulmonary vessels, the pulmonary arterial pressure increasing markedly in the adulthood, contrary to the large ventricular septal defects where severe PAH is ussulay present at birth.
Key words: PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL CARDIAC SHUNTS, CONGENITAL HEART DEFECT