Abstract
An: 2013, Nr.4, Articol Nr. 5
Title: 

MAGAINS AND CECROPINS, CYTOTOXIC PEPTIDES WITH MULTIPLE BIOLOGICAL EFFECTS

Authors: 

      R. Anghel - University of Medicine and Pharmacy “Gr. T. Popa” Iaşi, PhD student – Department of Anatomy
      Daniela Jitaru - Laboratory of Immunologyand Genetics “St. Spiridon” Hospital Iași
      L. Bădescu - University of Medicine and Pharmacy “Gr. T. Popa” Iaşi, Department of Cell and Molecular Biology
      Iris Bararu, Manuela Ciocoiu, Magda Bădescu - University of Medicine and Pharmacy “Gr. T. Popa” Iaşi, PhD – Department of Pathophysiology
      MAGAINS AND CECROPINS, CYTOTOXIC PEPTIDES WITH MULTIPLE BIOLOGICAL EFFECTS (Abstract): peptides, also called natural antimicrobial peptides, play a key role in immune defence against infections. In addition to antibacterial action and modulation of the immune response of these peptides, recent studies indicated that a part of these cytotoxic peptides that have an effect on bacteria but not on normal mammal cells, exercise a significant cytotoxic action on cancer cells. Natural antimicrobial peptides have in general a low molecular weight. Their structure is amphiphitic, having two regions, on the one hand, one hydrophile and another hydrophobe, and on the other hand, a peptide structure, and the net electric charge is intensely positive. Magains with a a heliciodal structure are the most important peptides of the type that has a strong pore forming activity in gram positive and gram negative bacteria membranes, fungi, yeast and viruses. Cecropins are bioactive peptides which interact with cell membranes forming a transmembrane channel which facilitate free circulation of electrolytes, metabolites and water. A special social interst for these investigations lies in the necessity to develop innovative antimicrobial therapies stemming from physiological resistence classical antibiotics and, also from side effects of conventional therapies. On the other hand, in spite of progress in cancer treatment, there is an international interest in developing new techniques and finding new therapeutic agents with excellent anti tumor effect and with fewer side effects, in order to improve prognosis and increase the rate of survival of patients with tumor pathology.
Key words: CYTOTOXIC PEP¬TIDES, ANTIMICROBIAL PEPTIDES, MAGAIN I, MAGAIN II, CECROPIN A, CE¬CROPIN B, LOW MOLECULAR WEIGHT, ANTIMICROBIAL ACTION, HUMAN TUMOR
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