Abstract
An: 2013, Nr.4, Articol Nr. 4
Title: 

MAGNESIUM AND ZINC INFLUENCE ON FEMALE GENITAL TRACT IN EXPERIMENTAL INDUCED DIABETES MELLITUS

Authors: 

      Cristina Galeş, Carmen Lăcrămioara Zamfir - University of Medicine and Pharmacy “Gr.T. Popa” Iasi, Department of Histology
      M. Nechifor - University of Medicine and Pharmacy “Gr.T. Popa” Iasi, Department of Pharmacology
      B. Stoica - University of Medicine and Pharmacy “Gr.T. Popa” Iasi, Department of Biochemistry
      C.I. Stan - University of Medicine and Pharmacy “Gr.T. Popa” Iasi, Department of Anatomy
      MAGNESIUM AND ZINC INFLUENCE ON FEMALE GENITAL TRACT IN EXPERIMENTAL INDUCED DIABETES MELLITUS(Abstract): Experimental and clinical data sustain the connection between diabetes mellitus and altered female reproductive function. Our animal research tested the influence of magnesium and zinc instreptozotocin (STZ) induced diabetes mellitus in non pregnant female rats.The study was performed on four groups, each one consisting of eight non pregnant adult Wistar female rats, raised in usually laboratory conditions. The first group of female rats was the control group and did not receive any substance, thesecond group received STZ 60mg/kg i.p, (unique dose), the next group received STZ+ daily MgCl2 1 mmol/kg/day i.p. for 8 weeks and the last group received STZ+ZnCl20.05mmol/ kg/day daily i.p. for 8 weeks. There were determined blood glucose level, total plasma Mg concentration, the animals total antioxidant capacity(TAS), before the STZ administration and after 8 weeks, At the end of the experiment, the animals were anesthetized and sacrificed. The obtained results were statistically interpreted by ANOVA test. Our experiment revealed that both magnesium and zinc decreased the number of atretic follicles and improved the endometrium thickness but only magnesium significantly increased the number of primordial follicles. Magnesium and zinc increased the TAS values (reduced by STZ).
Key words: DIABETES, STREPTOZOTOCIN, ZINC, MAGNESIUM, OVARY, ENDOMETRIUM
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