Abstract
An: 2013, Nr.2, Articol Nr. 3
Title: 

DEVELOPMENT OF THE THYROID ANGIOFOLLICULAR UNITS

Authors: 

      Ioana Ruxandra Rusu, Angela Ilie, Carmen Stanescu, F.M. Filipoiu - University of Medicine and Pharmacy “Carol Davila”, Bucharest, 2nd Preclinic Departament – Morphological Scienses
      DEVELOPMENT OF THE THYROID ANGIOFOLLICULAR UNITS (Abstract): The thyroid gland development is closely correlated with the evolution of pharyngeal arches. This gland appears from foramen caecum, in the floor of the pharynx, between tuberculum impar and the copula, at 21 days of gestation. Subsequently occurs a process of descensus and thyroid reaches the level of the definitive position. In weeks 18 20, the hypothalamus secretes TRH, adenohipofiza TSH and thyroid thyroxin T4. T3 level remains low until 30 weeks of gestation. The present study uses microscopic sagittal and frontal sections, stained haematoxylin eosin and Pappenheim, sections that allow to describe the three types of cells: follicular cells, that produce the colloid and will be involved in the thyroid hormones synthesis; parafollicular cells, located in the follicular interstitium, which secretes calcitonin; endothelial cells of parafollicular vessels, that form, together with the follicular cells, the angiofollicular units. From the functional point of view, it is necessary to describe the angiofollicular unit, responsible for the modifications of the histological thyroid structure, which changes after 20 weeks of gestation. Anomalies of development at this level create thyroid dysgenesis. Therapeutic solutions require knowledge of embryonic development, which will determine the macro and microscopic anatomical structure.
Key words: THYROID PRIMORDIUM, FOLLICULAR CELL, THYROID ANGIO¬FOLLI¬CULAR UNIT.
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