Abstract
An: 2013, Nr.1, Articol Nr. 13
Title: 

THE EFFECTS OF HYDROXYMETHYLGLUTARYL COENZIME A REDUCTASE INHIBITORS IN ELDERLY PATIENTS

Authors: 

      Maria-Magdalena Leon, F. Mitu - University of Medicine and Pharmacy „Gr. T. Popa” Iași, Faculty of Medicine, Medical Semiology Department
      Elena Stefanachi - Rehabilitation Hospital Iași, Pathology Department
      Roxana Cobzaru - Rehabilitation Hospital Iași, Parasitology Department
      THE EFFECTS OF HYDROXYMETHYLGLUTARYL COENZIME A REDUCTASE INHIBITORS IN ELDERLY PATIENTS (Abstract): The need to treat dyslipidemia in elderly patients in order to reduce coronary risk is the key of primary and secondary prevention. The atherosclerosis process is the same in the elderly as in adults, and the response to the treatment is also the same. In addition, two particularly important elements regarding this segment of the population are emphasized: the biological age becomes more important than the chronological age, and the quality of life remains equally very important. Our study aims to monitor the dyslipidaemic elderly (120 patients) for a period of 6 weeks and also to set the hygienic-dietary treatment (group I) or medication (group II), with the supervision of lipids levels. It was found that the maximum number of dyslipidaemic patients (75%) are aged between 65-80 years old, with a significantly higher percentage of men (72.5%), weighing between 85-100 kg (71.66%). Risk factors taken into account were: smoking present in 33.33%, coffee consumption (43.33%), alcohol (8.33%), but the most important one was physical inactivity (62.5%). In group I, the hygienic-dietary therapy did not change significantly the triglycerides levels in any determination; however the total cholesterol decreased significantly after 3 weeks, but remained constant after 3 weeks. In group II, the drug treatment determined the significant decrease of cholesterol and triglycerides level in both determinations. Therefore, treatment with HMG-CoA reductase inhibitors in combination with cholesterol-lowering diet effectively controls the dyslipidemia of elderly patients. The attempts to correct the lipid profile by diet proved unsuccessful, possibly due to the decrease of patients’ compliance as the period of time from the start of the diet increases.
Key words: HYDROXYMETHYLGLUTARYL COENZIME, DYSLIPIDEMIA
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