Abstract
An: 2012, Nr.2, Articol Nr. 4
Title: 

HISTOLOGICAL MODIFICATIONS IN THE PLACENTA IN PREGNANCY INDUCED HYPERTENSION AND PREMATURITY

Authors: 

      Corina Daniela Frandes, M.F. Sferdian, Lavinia Daniela Stretcu, Adriana Radu - “Vasile Goldiş” Western University of Arad
      C. Nisipasu - University „Titu Maiorescu” Bucuresti, Faculty of Dental Medicine
      HISTOLOGICAL MODIFICATIONS IN THE PLACENTA IN PREGNANCY INDUCED HYPERTENSION AND PREMATURITY (Abstract): Purpose: Presenting the most important structural modifications of the placenta on the maternal face, in pregnancy induced hypertension (PIH) and prematurity. Material and Method: We have studied the main microscopical modifications of 84 placentas obtained after delivery for two unequal groups: the study lot L1=63, representing mothers with PIH and prematurity and another control lot L2 = 21 normotensive mothers at term. The samples obtained by sections were specificaly prepared for the study with morphological HE staining, a histochemical stain Masson’s Trichrome technique and immunohistochemical staining using monoclonal anti-Human Cytokeratin and monoclonal anti-Human Ky 67. For the histological examination we used optical microscopy for observing mainly the lumen of arteriole and stomal changes. Results: We registered the following structural modifications in the pregnancies with PIH versus normal ones: changes in endothelium fibrinoid necrosis, the hypert­rophy of tunica media, bridging syncytial knots, avascular small terminal villi with hyaline fibrosis of the stroma and the thrombosis of the terminal arterioles. Conclusions: A better understanding of the immunohistological damages demonstrated through our study, concerning the preeclamtic maternal face of the placenta, will change in the future.
Key words: PREGNANCY INDUCED HYPERTENSION, FETAL CHRONIC HYPOXEMIA, MATERNAL SURFACE OF THE PLACENTA, HISTOLOGICAL MODIFICATIONS; MONOCLONAL ANTIBODIES
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