Abstract
An: 2011, Nr.3, Articol Nr. 4
Title: 

THE PROTECTIVE EFFECTS OF SOME VEGETABLE ACTIVE PRINCIPLES IN ANIMALS EXPOSED TO ULTRAVIOLET RADIATION

Authors: 

      R.V. Lupușoru - University of Medicine and Pharmacy “Gr.T. Popa”, Iaşi, Faculty of Medicine, Pathophysiology Department, PhD student
      Carmen Zamfir - University of Medicine and Pharmacy “Gr.T. Popa”, Iaşi, Faculty of Medicine, Histology Department
      Cătălina-Elena Lupușoru - University of Medicine and Pharmacy “Gr.T. Popa”, Iaşi, Faculty of Medicine, Pharmacology Department, Faculty of Pharmacy
      Carmen Gafițeanu - University of Medicine and Pharmacy “Gr.T. Popa”, Iaşi, Faculty of Medicine, Pharmaceutical Technology Department
      Maria Marinescu - Malvifarm, Bacău
      Magda Bădescu - University of Medicine and Pharmacy “Gr.T. Popa”, Iaşi, Faculty of Medicine, Pathophysiology Department
      THE PROTECTIVE EFFECTS OF SOME VEGETABLE ACTIVE PRINCIPLES IN ANIMALS EXPOSED TO ULTRAVIOLET RADIATION (Abstract): The aim of this paper was to investigate the local protective effect of an ointment containing 2% aqueous extract of Syringa vulgaris in animals exposed to ultraviolet radiation (UVR). Material and methods: The experiments were carried out on Wistar rats (180-200 g), divided in 4 groups of 10 animals each (coded L1-L4). The L1 group was the control group, the animals in L2 were exposed to UV, the rats in L3 received topical administration of the S. vulgaris ointment and the L4 group received the tested extract and was daily exposed to UVR. All the animals included in the experiment had their back hair removed. The groups exposed to UVR (l = 100-400 nm) received 2.4 J/cm2, 15 minutes/day, 28 days. At the end of the experiment all the animals were sacrificed and we determined the superoxide dismutase (SOD) and malondialdehyde (MDA) activity levels and skin fragments from the exposed area were harvested for histopathological evaluation. Results and discussion: The animals exposed to UVR had higher values of SOD and MDA activity. The vegetable extract had a protective effect by reducing the variations of the enzymes activity in animals exposed to UV. The histopathological evaluation showed a smaller number of inflammatory cells in animals receiving the tested extract and UV exposure compared to the animals without any protection. The tested extract determined no histopathological variations compared to the control group. Conclusion: The tested extract showed protective effects without local toxicity and can represent a possible alternative to the products already on the market.
Key words: ULTRAVIOLET RADIATION, SYRINGA VULGARIS, OXIDATIVE STRESS
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