Abstract
An: 2011, Nr.2, Articol Nr. 6
Title: 

CTGF AND CYR61 EXPRESSION IN NORMAL WISTAR RAT GINGIVAL TISSUES

Authors: 

      Mihaela Mitrea - Iasi “Gr. T. Popa” University of Medicine and Pharmacy, Tutor, Department of Anatomy
      L.L. Francu - Iasi “Gr. T. Popa” University of Medicine and Pharmacy, Assistant professor, Department of Anatomy
      Dorelia Lucia Calin - Iasi “Gr. T. Popa” University of Medicine and Pharmacy, Assistant, Department of Cariology and Odontotherapy
      CTGF AND CYR61 EXPRESSION IN NORMAL WISTAR RAT GINGIVAL TISSUES (Abstract): Sometimes, the term growth factor is used in parallel with the term cytokine. Historically, cytokines have been associated with the hematopoietic and immune system cells. CCN protein family has six multifunctional members. CTGF is a “matricell” factor that collaborates with other growth factors, growth factor receptors, extracellular matrix and its receptors. Cyr61 protein promotes cell proliferation, chemotaxis, angiogenesis, and cell adhesion. Material and method: The study was carried out on 4 series of 5 adult, male Wistar rats each, weighing 260±23 g. The positive reactions were observed with a Nikon microscope and consisted in the occurrence of a brown precipitate with cytoplasmic pattern corresponding to the location of the monitored molecules. Results and discussions: The results regarding CTGF expression revealed an extremely wide variation in the presence of this molecule, 4 of 5 rats presenting staining only at the level of some capillary endothelia in lamina propria and not in the gingival epithelium. Cyr61 expression in the investigated series partially overlaps that of CTGF. Conclusions: CTGF molecule expression greatly varies within the same series. Cyr61 expression partially overlaps CTGF expression. This heterogenicity within the same animal series demonstrates that the occurring tissue per¬turbations might be of different degrees, probably due to some individual peculiarities.
Key words: CTGF, Cyr61, GROWTH AFCTORS, GINGIVAL TISSUES
archive
Current edition
2021
Previous editions