Abstract
An: 2011, Nr.2, Articol Nr. 20
Title: 

RESECTION MARGINS IN CUTANEOUS MALIGNANT MELANOMA

Authors: 

      Cristina Stănescu, Camelia Tamaş, Doiniţa Rădulescu, L. Popa, T. Stamate - University of Medicine and Pharmacy „Gr.T. Popa” Iaşi, Faculty of Medicine, Department of Plastic Surgery and Reconstructive Microsurgery
      RESECTION MARGINS IN CUTANEOUS MALIGNANT MELANOMA (Abstract): We studied the differences between melanoma survival after various resection margins and correlation with lymph node metastasis and relapses. Patients and methods. This study includes a total of 263 patients diagnosed with malignant melanoma between 2000 – 2008. We made a multivariate analysis to estimate survival rates regarding resection margins using Kaplan Meier survival curves and Cox proportional hazards model. Results. For patients with resection margins at 1 2 cm, the 3 years survival rate was 59, 40% and the frequency of relapses was 29, 7%, for those with resection margins at 2 3 cm, the 3 years survival rate was 54, 43% and the frequency of relapses was 25, 3%. For more than 3 cm resection margins, the 3 year survival rate wasn’t increased (47, 74%), but the frequency of relapse decreased to 23, 8%. The tumour size has no influence to survival rate. In stage I the survival rate was 95 %, in stage II was 64, 8 %, in stage III A was 57, 14 % and in stage III B was 43, 5 %. The presence of cutaneous metastases stage (III C) decreased the survival rate to 12, 5 % and systemic metastases (stage IV) decreased dramatically the survival rate to 9, 4 %. Conclusions. Surgery remains the main option in melanoma therapy of all sites. Survival rate are not improved with resection margin increasing. Early diagnosis combined with appropriate surgical therapy is currently the most important step in melanoma treatment.
Key words: CUTANEOUS MELANOMA, RECCURENCE, MELANOMA SURGERY, SENTINEL NODE BIOPSY, REGIONAL METASTASES, MORTALITY
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