Abstract
An: 2010, Nr.2, Articol Nr. 9
Title: 

THE ROLE OF ION CHANNELS IN THE COLLECTION, TRANSMISSION AND ANALYSIS OF PAIN STIMULI

Authors: 

      B. Oprişan - The University of Medicine and Pharmacy ““Gr. T. Popa”” Iași, The Faculty of Medicine, Biophysics and Medical Physics Department
      C.I. Stan, T. Ţăranu, D.C. Popescu - The University of Medicine and Pharmacy ““Gr. T. Popa”” Iași, The Faculty of Medicine, Anatomy Department
      G. Roiu - The University of Oradea, The Faculty of Medicine and Pharmacy
      THE ROLE OF ION CHANNELS IN THE COLLECTION, TRANSMISSION AND ANALYSIS OF PAIN STIMULI (Abstract): Pain disposes of specific anatomical formations, organized on various levels: neurons from the spinal and trigeminal ganglions, from the dorsal horn of the spinal corn, thalamus and the cerebral and the cortex. The results obtained by the researchers have mentioned the connection between the pain and the ion channels beginning with the perception of the nociceptive stimuli that have the possibility to transform the mechanical, thermal or chemical energy into electrical signals. They will be transmitted by means of the sodium channels voltage-dependent and at the level of the neuronal synapses by the calcium voltage-dependent ones. The modern methods of research such as cloning a certain type or subtype of ion channel, increasing the neurons in cultures, patch-clamp, gene mutations, data of molecular biochemistry, have succeeded to identify various types of ion channels, their molecular structure, location and way of interfering in the painful sensations. It is obvious that a certain type of ion channel involved in pathogeny becomes a therapeutical target. We hope that in the future molecules able to act aimed on certain types of channels will be identified, situated at a certain level of the nervous system in order to improve the activity of the opioids or to directly fight against the pain.
Key words: ION CHANNELS, NOCICEPTIVE STIMULI, THE NERVOUS SYSTEM, THERA­PEUTIC TARGETS
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