Abstract
An: 2010, Nr.2, Articol Nr. 18
Title: 

METABOLIC ACIDOSIS IN SEPSIS IN INFANTS AND SMALL CHILDREN

Authors: 

      R. Ciobotaru - PhD, University of Medicine and Pharmacy, ““Gr.T. Popa”” Iași; ATI Branch, General Hospital CFR Galați
      O. Ciobotaru - Department of Surgery, General Hospital CFR Galați
      V. Ardeleanu - Faculty of Medicine and Pharmacy Galati, Department of Anatomy
      M. Burlea - V-th Gastroenterology Clinic, Emergency Hospital ““St. Maria”” Iași
      METABOLIC ACIDOSIS IN SEPSIS IN INFANTS AND SMALL CHILDREN (Abstract): Electrolyte and acid-base disorders in sepsis are a consequence of the body’s response to shock and are responsible for some of the signs and symptoms that occur in this condition. Metabolic acidosis is the main change in the acid- base balance in sepsis. Hypoperfusion, caused by acidosis and inflamatory mediators, in association with decreased production of ATP, a direct consequence of acidosis, leading to slow processes of maintaining cellular integrity leanding to irreversible cell injury and death. Material and Method: I performed a retrospective study on 64 patients aged between one month and seven years, who were hospitalized with diagnosis of sepsis in the intensive care unit of Emergency Hospital “St. Mary “ Iasi, in 2007, 2008 and first quarter of 2009. Results: In 16 cases during hospitalization in intensive care, the pH was below 7.3; in 20 cases pH was below 7.35; in 14 cases, pH values were within normal limits, and in 14 cases pH was over 7.45. There were 16 deaths: 12 with pH <7.3, two cases with pH <7.35 and in two cases was seen alkalosis (pH> 7.45). 30 subjects (83.33%) had metabolic acidosis and only six (16.66%) had respiratory acidosis. Conclusions: Irreversible cellular modification seems to occure faster in very young children. 50% of died patients had metabolic acidosis and under one year old.
Key words: METABOLIC ACIDOSIS, SEPSIS, CELULAR MODIFICATION, INTENSIVE CARE
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