Abstract
An: 2010, Nr.1, Articol Nr. 9
Title: 

IMMUNOHISTOCHEMICAL EVALUATION OF SOD IN OXIDATIVE STRESS IN LUNG

Authors: 

      Carmen Zamfir, Raluca Temneanu, Lelioara Tocan, Elena Cojocaru, Cristina Galeş - “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Discipline of Histology
      IMMUNOHISTOCHEMICAL EVALUATION OF SOD IN OXIDATIVE STRESS IN LUNG (Abstract): Oxidative stress is recognized as a real alterative process, acting as a mediator of cellular and tissular damages, extrapolated in acute and chronic diseases. During this stress, a great number of so called “reactive oxygen species” are produced and discharged in the whole organism; their overproduction is able to generate pathologic responses. SOD are specific enzymes with antioxidant activity, which catalyse the dismutation of superoxide to hydrogen peroxide. In lungs, which are normally exposed to high oxygen concentrations, SOD constitutes the first defence line against oxidant agents. Immunohistochemical techniques detect the presence of SOD in pulmonary tissue, being applicable in lung tissue sections. The immunolocation of different forms of SOD can offer a better perspective on specific pulmonary targets, because they are not diffusely located and dispersed throughout the lung. The benefits of immunohistochemistry studies involved the fact that the localization and if it is possible, the quantification of SOD activity in tissues can give information about tissular response to oxidative stress.
Key words: IMMUNOHISTOCHEMISTRY, LUNG, SOD, ANTIOXIDANTS
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