An: 2012, Nr.4, Articol Nr. 5
USE OF CD34 EXPRESSION IN THE ASSESSMENT OF ANGIOGENESIS IN COLORECTAL CARCINOMA
Delia Hânganu, M.V. Hânganu, L.L. Frâncu - ”Gr. T. Popa” University of Medicine and Pharmacy Iasi, Anatomy Discipline
USE OF CD34 EXPRESSION IN THE ASSESSMENT OF ANGIOGENESIS IN COLORECTAL CARCINOMA (Abstract): Colorectal malignant pathology substantially changes vascular architecture, neoangiogenessis having distance implications. In descending order of frequency, three histological forms of cancer affects rectum: adenocarcinoma, mucoid or colloid carcinoma and anaplastic carcinoma cell with high degree of indifference cell. The study included a group of 24 patients diagnosed with colorectal cancer who were evaluated at the Laboratory of Pathology imunohostochimic and morgue of Military Emergency Hospital ”Dr. Jacob Czihac” Iasi. We quantified microvascular density in the area of active angiogenesis, assessing the sensitivity and specificity of the endothelial marker CD34. CD34 immunohistochemical examination of stained sections showed that vessels are present in the tumor stromal tissue without notice any reaction with tumor cells. The quantification of tumoral angiogenesis can allow the division of patients according to the type of treatment and can also permit the management selection in the long run for the individuals with low tumoral microvascular density. Seriate determination of protein CD34 every 6 months can play the part of a cancer progression or regression marker and stands for a new tool in assessing the prognosis of these tumors.
Key words: CD34 EXPRESSION, COLO-RECTAL CANCER, PROGNOSTIC FACTOR