An: 2012, Nr.3, Articol Nr. 3
THE ACTION OF STATINS AND FIBRATES ON BONE STRUCTURE AND FRACTURE HEALING PROCESS
R. S. Şipoş, Zsuzsanna Pap, Z. Pávai - University of Medicine and Pharmacy, Târgu Mureş, Faculty of Medicine, Department of Anatomy and Embriology
Ioana Şuş - University of Medicine and Pharmacy, Târgu Mureş, Faculty of Medicine
THE ACTION OF STATINS AND FIBRATES ON BONE STRUCTURE AND FRACTURE HEALING PROCESS (Abstract): The most commonly used hypolipemiant agents are statins and fibrates. Several studies have shown different pathways that relate these drugs with bone metabolism. As both dyslipidemia and osteoporosis are frequent in elderly patients, statins and fibrates might become a dual purpose therapy. In this study we aimed to compare the effect of the two drugs on healthy and osteoporotic bone and also on the fracture healing process. For our experimental study we used Wistar female rats divided into 6 groups, half of them being ovariectomized and all suffered a mediodiaphysary fracture. Each group was treated with simvastatin, fenofibrate 10mg/kg daily or received no treatment respectively. Bone structure and fracture healing were evaluated at 2, 4, 6 and 8 weeks post fracture by histological means, with haematoxylineosine staining. On bone structure, at week 6 and 8 statins reduced the bone trabeculas size on nonovariectomized rats, but increased them in osteoporotic rats, while fibrates showed no difference in comparison with the control groups. The fracture healing process was enhanced when simvastatin was administred, regardless if the bone was osteoporotic or not. At the same time, no obvious positive effect of fenofibrate on fracture healing process was observed, the outcome of the fracture being similar in fenofibrate treated rats and control group, both without osteoporosis. In this study, simvastatin had a better positive effect on bone than fenofibrate, which might recommend statins as a double potential drug in dylipidemic and osteoporotic patients.
Key words: STATINS, FIBRATES, OSTEOPOROSIS, FRACTURE, BONE STRUCTURE