Abstract
An: 2017, Nr.4, Articol Nr. 1
Title: 

PRELIMINARY EXAMINATION OF THE HISTOLOGICAL ASPECTS OF HUMAN FETAL KIDNEY

Authors: 

      G. Ráduly, Zsuzsánna Pap, L. Dénes, Annamária Szántó, A. Ghizdavăţ, Z. Pávai - University of Medicine and Pharmacy of Tîrgu Mureş, Department of Anatomy and Embryology
      V.E. Lungu - University of Medicine and Pharmacy of Tîrgu Mureş, Student, Faculty of Medicine
      PRELIMINARY EXAMINATION OF THE HISTOLOGICAL ASPECTS OF HUMAN FETAL KIDNEY (Abstract): Introduction: The histology of fetal kidney differs significantly from the adult kidney, because the nephrogenesis, the synthesis of new nephrons, lasts until the end of the fetal period. The kidney develops from two mesodermal primordia: the metanephric blastema forms from the intermediate mesoderm and the ureteric bud forms from the mesonephric duct. Materials and methods: We studied the histological structure of the fetal renal tissues in 18 post mortem fetuses from the Department of Anatomy and Embryology, University of Medicine and Pharmacy Tîrgu Mureş. Results: On HE stained sections we identified the nephrogenic zone and the developing nephrons in different stages of their development. We noted the increase of renal size, cortical thickness and the number of glomeruli. Discussion: Our results are similar with those in the literature data. In the nephrogenic zone of the cortex, which is formed by undifferentiated stell cells, newgenerations of nephrons appear during fetal life. The nephrogenic zone is composed of thick undifferentiated blastema cells. The newly formed nephrons are organized in layers: the oldest nephrons are located in the inner portion of the cortex, while the youngest nephrons are located in the outer layer of the cortex. Conclusion: The development of the nephron in humans follows the development of the nephron understood from the studies made on mice and rats.
Key words: FETAL KIDNEY, METANEPHRIC BLASTEMA, NEPHRON
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