Abstract
An: 2015, Nr.1, Articol Nr. 17
Title: 

OCT EVALUATION OF THE RETINAL NERVE FIBER LAYER FOR THE PATIENTS WITH GLAUCOMA AND DIABETES MELLITUS

Authors: 

      O.I. Motaş, D. Chiseliţă, Nicoleta Anton Apreutesei - “Grigore T. Popa” Iaşi University of Medicine and Pharmacy, Department of Ophtalmology
      OCT EVALUATION OF THE RETINAL NERVE FIBER LAYER FOR THE PATIENTS WITH GLAUCOMA AND DIABETES MELLITUS (Abstract): The aim of the paper was the evaluation of the modifications of the retinal nerve fiber layer for the patients with primary open angle glaucoma or ocular hypertension associated with diabetes mellitus. Material and method: a prospective study that included a number of 25 patients. The study group was made up of 17 patients: 12 patients with primary open angle glaucoma (POAG) and diabetes mellitus and 5 patients with ocular hypertension (OH) and diabetes mellitus. The control group included 8 patients without glaucoma. All the patients with an accurate diagnosis of primary open angle glaucoma and intraocular hypertension that were medically and/or surgically treated or not, associated with diabetes mellitus, were included in the study. The patients with other types of glaucoma (closed angle, pigmentary, cortisone related, pseudoexfoliative), the ones without an accurate diagnosis of glaucoma or without associated diabetes mellitus were excluded. The control group was made up of subjects without a glaucoma diagnosis or clinical elements related to glaucoma, without surgical interventions in their medical records. All participants were evaluated with CIRRUS HD-OCT. Results: The average thickness of the retinal nerve fiber layer (RNFL) in the group with glaucoma and diabetes was slightly lower as compared to the other two groups. The most important thinning was noticed in the upper and the lower sector in the glaucoma group as compared to the other two groups. There were no significant differences from the statistical point of view between the intraocular hypertension group and the normal subjects. There were significant differences from the statistical point of view and a negative correlation in the glaucoma and ocular hypertension group regarding the MD, PSD and the thickness of the RNFL. Conclusions: There were no statistically significant differences between the intraocular hypertension group and the healthy subjects regarding the average thickness of the RNFL. There was a decrease of the RNFL thickness for the patients with glaucoma and diabetes as compared to the other two groups, but without statistical importance (p=0.056). The presence of diabetes did not influence the modifications caused by glaucoma. Big prospective studies on extended lots of patients were necessary.
Key words: POAG, OH, RNFL, CIRRUS HD-OCT, DIABETES MELLITUS
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