Abstract
An: 2012, Nr.1, Articol Nr. 3
Title: 

THE EFFECT OF BLEOMICINE ON ANGIOGENESIS

Authors: 

      Zsuzsánna Kertész, Z. Pávai - University of Medicine and Pharmacy Târgu-Mureș
      G. Bălă - Emergency Hospital Târgu-Mureș, Pediatric Surgery
      M. Raica, Anca Maria Cîmpean - University of Medicine and Pharmacy Timişoara, Department of Histology
      THE EFFECT OF BLEOMICINE ON ANGIOGENESIS (Abstract): Objective: Despite various treatment utilised, vascular anomalies represent difficulty in many cases for physicians. The Bleomycin is a cytotoxic antitumoral antibiotic, that cose modifications of DNA. It has been also successfully used in intralesional injection treatment of cystic hygromas and haemangiomas, based specifically on a high sclerosing effect on vascular endothelium. We used this agent in the treatment of congenital haemangiomas and lymphangiomas, with various results. Therefore we tried to work out an experimental model, to better understand the mechanism of this substance, and the differences on the results. Method: We used the chick embryo chorioallantoic membrane (CAM) to study the effect of Bleomicine on the angiogenesis. Results: After three days of bleomycin administration, we noticed several histopatological changes on CAM treated with bleomycin: thickness decreases and stroma densification occurs; tendency of the figurative elements to extravasate in the stroma; large vessels, wich keeps the form of blood vessels, but the red blood cells are agglutinated, with stasis, thrombosis; the endothelium is no longer visible morphological. Conclusions: Histopathological changes observed on the CAM treated with bleomycin supports our teory, that this substance in addition to the specific sclerosing effect on vascular endothelium, also has an inhibitory effect on angiogenesis, wich would explain wy the treatment goes better on younger children.
Key words: HAEMANGIOMA, BLEOMICIN, ANGIOGENESIS
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